Targeting the translation machinery in cancer | Nature


Dysregulation of mRNA translation is a frequent occurrence in cancer cells, and several components of the translation machinery have emerged as promising targets for anticancer therapeutics. This

The apoptotic machinery as a biological complex system

The omic characterization of the apoptotic machinery: a model for a system biology approach to Homo sapiens biopathology. Understanding the molecular bases of complex and biomedically important phenotypes, as cancer and degenerative diseases, is one of the critical challenges for contemporary BioMedicine [ 14, 78 ].

IAS 16: Property, plant and equipment | ICAEW

Full-text standard. The IFRS Foundation and International Accounting Standards Board (IASB) provides free access to the consolidated unaccompanied international accounting standards for the current year through its website; you will need to register to gain access.

Full text of "Canadian Machinery" archive

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[Full text] Single-nucleotide polymorphisms of microRNA

Dec 03, 2014· Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer Yufei Zhao, Yanming Du, Shengnan Zhao, Zhanjun GuoDepartment of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of ChinaObjective: MicroRNA (miRNA)-related single-nucleotide polymorphisms

:OncoTargets and Therapy · 2015:Yufei Zhao · Yanming Du · Shengnan Zhao · Zhanjun Guo:Text mining · Bioinformatics

IJMS | Free Full-Text | Designed Elastic Networks: Models

We discuss the prospects of designed protein-mimicking elastic networks as model systems to elucidate the design principles and functional signatures underlying the operation of complex protein machinery. View Full-Text

Computing Machinery and Intelligence Wikipedia

"Computing Machinery and Intelligence" is a seminal paper written by Alan Turing on the topic of artificial intelligence. The paper, published in 1950 in Mind, was the first to introduce his concept of what is now known as the Turing test to the general public.

UN Charter (full text) | United Nations

UN Charter (full text) WE THE PEOPLES OF THE UNITED NATIONS DETERMINED to save succeeding generations from the scourge of war, which twice in

The molecular machinery of regulated cell death | Cell


The scientific observation of regulated cell death (RCD) historically began in 1842 when Karl Vogt noticed dying cells in toads. However, the surge in RCD research only started when the term

The Machinery of Freedom David D. Friedman

The Machinery of Freedom file:///C|/and%20Settings/Rafael/Meus%20documentos/Downloads/Friedman,%20David%20-%20The%20Machinery%20of%20Freedom.html[14/3/2009 16:59:08]

No strings attached: the ESCRT machinery in viral budding

Since the initial discovery of the endosomal sorting complex required for transport (ESCRT) pathway, research in this field has exploded. ESCRT proteins are part of the endosomal trafficking system and play a crucial role in the biogenesis of multivesicular bodies by functioning in the formation of vesicles that bud away from the cytoplasm.

Viral manipulation of the cellular sumoylation machinery

Jul 14, 2017· Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has emerged as an important post-translational modification that is manipulated by viruses to modulate anti-viral responses, viral replication, and viral pathogenesis.

IAS 16 Property, Plant and Equipment IFRS

The IFRS Foundation's logo and the IFRS for SMEs® logo, the IASB® logo, the 'Hexagon Device', eIFRS®, IAS®, IASB®, IFRIC®, IFRS®, IFRS for SMEs®, IFRS Foundation®, International Accounting Standards®, International Financial Reporting Standards®, NIIF® and SIC® are registered trade marks of the IFRS Foundation, further details of which are available

Gating machinery of InsP3R channels revealed by electron


Oct 12, 2015· Gating machinery of InsP 3 R channels revealed by electron cryomicroscopy. Abstract Inositol-1,4,5-trisphosphate receptors (InsP 3 Rs) are ubiquitous ion channels responsible for cytosolic Ca 2+ signalling and essential for a broad array of cellular processes ranging from contraction to secretion, and from proliferation to cell death.

Full text of "Machinery"

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The molecular machinery of regulated cell death | Cell


h Autophagy-dependent cell death is driven by the molecular machinery of autophagy. i Alkaliptosis is driven by intracellular alkalinization after IKBKB-NF-B pathway-dependent downregulation of CA9.

full text of machinery


full text of machinery CrossRef Full Text sciencesciencemagorg OpenUrl Abstract / FREE Full Text Acknowledgments: The authors are thankful for insight and helpful discussions from N Elia, B Kopek, and B Lorenz The authors are grateful to R Villasmil for assistance with flow

ICS International Organization for Standardization

1.2 The ICS should facilitate the harmonization of information and ordering tools such as catalogues, selective lists, bibliographies, and databases on magnetic and optical media, thus promoting the world-wide dissemination of international, regional and national stand ards and other normative documents.

Property, Plant, and Equipment (Topic 360)

structure or equipment attached to the real estate that cannot be removed and used separately without incurring significant cost. Examples include an office building, a

Directive 2006/42/EC new machinery directive Safety

May 17, 2006· Read the full text of the consolidated version of the Directive (including later amendments) Read the full text of the Directive National laws implementing this Directive Further information on this topic. European Commission's practical guide on the new machinery directive 2006/42/EC (English version)

It's my fault: Read full text of Rahul Gandhi's letter

Read the full text of Rahul Gandhi's letter after resignation here: It is an honour for me to serve the Congress Party, whose values and ideals have served as the lifeblood of our beautiful nation. I owe the country and my organisation a debt of tremendous gratitude and love.

April 2019 Full Rpt Text

1.7 percent March increase. Transportation equipment, also down two of the last three months, drove the decrease, $5.3 billion or 5.9 percent to $85.5 billion. New orders for manufactured nondurable goods increased $1.2 billion or 0.5 percent to $250.7 billion.

Dirigent domain-containing protein is part of the

Aug 27, 2013· This machinery includes ESB1 and the NADPH oxidase/peroxidase required for monolignol activation . During the initial development of the Casparian strip, this machinery occurs as equatorially located islands that produce patchy lignifications (6, 7). As Casparian strip development continues, these assembly islands coalesce, perhaps through the delivery of ESB1 and other

UN Charter (full text) | United Nations

UN Charter (full text) WE THE PEOPLES OF THE UNITED NATIONS DETERMINED to save succeeding generations from the scourge of war, which twice in our lifetime has brought untold sorrow to

Changes to Environment of Care and Life Safety Chapters

Changes to Environment of Care and Life Safety Chapters Related to Life Safety Code Updates Issued September 20, 2017 Environment of Care (EC) Chapter The hospital plans activities to minimize risks in the environment of care. Note 1: One or more persons can be assigned to manage risks associated with the management plans described in this